Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects
文献类型：期刊论文
| 作者 | Zhao, RT; Kong, W; Sun, MX; Yang, Y; Liu, WY; Lv, M; Song, SP; Wang, LH; Song, HB; Hao, RZ |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:21页码:17617-17629 |
| 关键词 | Silver Nanoparticles Antibacterial Activity Infectious-diseases Escherichia-coli Drug-delivery Oxide Nanomaterials Mechanisms Cells Resistance |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b03185 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Various silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites (GO-Ag) have received increasing attention owing to their antimicrobial activity and biocompatibility; however, their aggregation in physiological solutions and the generally complex synthesis methods warrant improvement. This study aimed to synthesize a polyethyleneimine (PEI)-modified and AgNP-decorated GO nanocomposite (GO-PEI-Ag) through a facile approach through microwave irradiation without any extra reductants and surfactants; its antimicrobial activity was investigated on Gram-negative/-positive bacteria (including drug-resistant bacteria) and fungi. Compared with GO-Ag, GO-PEI-Ag acquired excellent stability in physiological solutions and electropositivity, showing substantially higher antimicrobial efficacy. Moreover, GO-PEI-Ag exhibited particularly excellent long-term effects, presenting no obvious decline in antimicrobial activity after 1 week storage in physiological saline and repeated use for three times and the lasting inhibition of bacterial growth in nutrient-rich culture medium. In contrast, GO-Ag exhibited a >60% decline in antimicrobial activity after storage. Importantly, GO-PEI-Ag effectively eliminated adhered bacteria, thereby preventing biofilm formation. The primary antimicrobial mechanisms of GO PEI-Ag were evidenced as physical damage to the pathogen structure, causing cytoplasmic leakage. Hence, stable GO-PEI-Ag with robust, long-term antimicrobial activity holds promise in combating public-health threats posed by drug-resistant bacteria and biofilms. |
| 语种 | 英语 |
| WOS记录号 | WOS:000434101200013 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/29033]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Zhao, RT 2.Kong, W 3.Sun, MX 4.Yang, Y 5.Liu, WY 6.Lv, M 7.Song, SP 8.Wang, LH 9.Song, HB 10.Hao, RZ |
| 推荐引用方式 GB/T 7714 | Zhao, RT,Kong, W,Sun, MX,et al. Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(21):17617-17629. |
| APA | Zhao, RT.,Kong, W.,Sun, MX.,Yang, Y.,Liu, WY.,...&Hao, RZ.(2018).Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects.ACS APPLIED MATERIALS & INTERFACES,10(21),17617-17629. |
| MLA | Zhao, RT,et al."Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects".ACS APPLIED MATERIALS & INTERFACES 10.21(2018):17617-17629. |
入库方式： OAI收割
来源：上海应用物理研究所
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