Logic Catalytic Interconversion of G-Molecular Hydrogel
文献类型：期刊论文
| 作者 | Zhong, RB; Xiao, MS; Zhu, CF; Shen, XZ; Tang, Q; Zhang, WJ; Wang, LH; Song, SP; Qu, XM; Pei, H |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:5页码:4512-4518 |
| 关键词 | G-quadruplex Dna Nanostructure Horseradish-peroxidase Fluorescence Detection Sensitive Hydrogels Gold Nanoparticles Drug-delivery Ion Dnazymes Nanogels |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b17926 |
| 文献子类 | 期刊论文 |
| 英文摘要 | By incorporating hemin into G-quadruplex (G(4)) during cation-templated self-assembly between guanosine and KB(OH)(4), we have constructed an artificial enzyme hydrogel (AEH)-based system for the highly sensitive and selective detection of Pb2+. The sensing strategy is based on a Pb2+-induced decrease in AEH activity. Because of the higher efficiency of Pb2+ for stabilizing G(4) compared with the Pb2+ ions substitute K+ and trigger hemin release from G(4), thus giving rise to a conformational interconversion accompanied by the loss of enzyme activity. The Pb2+-induced catalytic interconversion endows the AEH-based system with high sensitivity and selectivity for detecting Pb2+. As a result, the AEH-based system shows an excellent response for Pb2+ in the range from 1 pM to 50 nM with a limit of detection of similar to 0.32 pM, which is much lower than that of the previously reported G(4)-DNAzyme. We also demonstrate that this AEH-based system exhibits high selectivity toward Pb2+ over other metal ions. Furthermore, two two-input INHIBIT logic gates have been constructed via switching of the catalytic interconversion induced by and Pb2+ or K+ and pH. Given its versatility, this AEH-based system provides a novel platform for sensing and biomolecular computation. |
| 语种 | 英语 |
| WOS记录号 | WOS:000424851600017 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/29062]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Zhong, RB 2.Xiao, MS 3.Zhu, CF 4.Shen, XZ 5.Tang, Q 6.Zhang, WJ 7.Wang, LH 8.Song, SP 9.Qu, XM 10.Pei, H |
| 推荐引用方式 GB/T 7714 | Zhong, RB,Xiao, MS,Zhu, CF,et al. Logic Catalytic Interconversion of G-Molecular Hydrogel[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(5):4512-4518. |
| APA | Zhong, RB.,Xiao, MS.,Zhu, CF.,Shen, XZ.,Tang, Q.,...&Li, L.(2018).Logic Catalytic Interconversion of G-Molecular Hydrogel.ACS APPLIED MATERIALS & INTERFACES,10(5),4512-4518. |
| MLA | Zhong, RB,et al."Logic Catalytic Interconversion of G-Molecular Hydrogel".ACS APPLIED MATERIALS & INTERFACES 10.5(2018):4512-4518. |
入库方式： OAI收割
来源：上海应用物理研究所
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