Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin's neck zipper region
文献类型：期刊论文
| 作者 | Qin, JY; Geng, YZ; Lu, G; Ji, Q; Fang, HP |
| 刊名 | CHINESE PHYSICS B
 |
| 出版日期 | 2018 |
| 卷号 | 27期号:2页码:- |
| 关键词 | Molecular-dynamics Motor Proteins Linker Binding Domain Force |
| ISSN号 | 1674-1056 |
| DOI | 10.1088/1674-1056/27/2/028704 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Docking of the kinesin's neck linker (NL) to the motor domain is the key force-generation process of the kinesin. In this process, NL's beta 10 portion forms four backbone hydrogen bonds (HBs) with the motor domain. These backbone hydrogen bonds show big differences in their effective strength. The origins of these strength differences are still unclear. Using molecular dynamics method, we investigate the stability of the backbone HBs in explicit water environment. We find that the strength differences of these backbone HBs mainly arise from their relationships with water molecules which are controlled by arranging the surrounding residue sidechains. The arrangement of the residues in the C-terminal part of beta 10 results in the existence of the water-attack channels around the backbone HBs in this region. Along these channels the water molecules can directly attack the backbone HBs and make these HBs relatively weak. In contrast, the backbone HB at the N-terminus of beta 10 is protected by the surrounding hydrophobic and hydrophilic residues which cooperate positively with the central backbone HB and make this HB highly strong. The intimate relationship between the effective strength of protein backbone HB and water revealed here should be considered when performing mechanical analysis for protein conformational changes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000426739900001 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/29113]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Qin, JY 2.Geng, YZ 3.Lu, G 4.Ji, Q 5.Fang, HP |
| 推荐引用方式 GB/T 7714 | Qin, JY,Geng, YZ,Lu, G,et al. Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin's neck zipper region[J]. CHINESE PHYSICS B,2018,27(2):-. |
| APA | Qin, JY,Geng, YZ,Lu, G,Ji, Q,&Fang, HP.(2018).Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin's neck zipper region.CHINESE PHYSICS B,27(2),-. |
| MLA | Qin, JY,et al."Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin's neck zipper region".CHINESE PHYSICS B 27.2(2018):-. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。