Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor
文献类型：期刊论文
| 作者 | Zhang, Y; Shuai, ZH; Zhou, H; Luo, ZM; Liu, B; Zhang, YN; Zhang, L; Chen, SF; Chao, J; Weng, LM |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2018 |
| 卷号 | 140期号:11页码:3988-3993 |
| 关键词 | Core-shell Nanocubes Silver Nanoparticles Gold Nanoparticles Dna Nanostructure Au Surface Nanoprobes Biosensors Platform Sensors |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.7b12772 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Analysis of biomolecules at the single-molecule level is a great challenge in molecular diagnostics, gene profiling, and environmental monitoring. In this work, we design a smart plasmonic nanobiosensor based on individual Au@Ag core-shell nanocube (Au@Ag NC) modified with tetrahedron-structured DNA (tsDNA) for detecting microRNA 21 (miR-21) at the single-molecule level. An average localized surface plasmon resonance (LSPR) scattering spectral wavelength shift of approximately 0.4 nm can be obtained for a single miR-21 hybridization event on the nanobiosensor. In addition, the sensing mechanism of the individual Au@Ag NC is further verified by the three-dimensional finite-difference time-domain (3D-FDTD) simulations. Notably, this system not only allows the real-time detection of miR-21 with an aM level sensitivity over a large dynamic range from 1 aM to 1 nM, but also enables DNA-based logic operations as well as biomemory by exploiting miR-21, KpnI, and StuI-responsive assays. Our study opens a unique method for single-molecule detection of biomolecules and thus holds great promise in a variety of biological and biomedical applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000428356000028 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/29138]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Zhang, Y 2.Shuai, ZH 3.Zhou, H 4.Luo, ZM 5.Liu, B 6.Zhang, YN 7.Zhang, L 8.Chen, SF 9.Chao, J 10.Weng, LM |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Shuai, ZH,Zhou, H,et al. Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2018,140(11):3988-3993. |
| APA | Zhang, Y.,Shuai, ZH.,Zhou, H.,Luo, ZM.,Liu, B.,...&Wang, LH.(2018).Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,140(11),3988-3993. |
| MLA | Zhang, Y,et al."Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140.11(2018):3988-3993. |
入库方式： OAI收割
来源：上海应用物理研究所
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