Valency-Controlled Framework Nucleic Acid Signal Amplifiers
文献类型：期刊论文
| 作者 | Liu, Q; Ge, ZL; Mao, XH; Zhou, GB; Zuo, XL; Shen, JW; Shi, JY; Li, J; Wang, LH; Chen, XQ |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018 |
| 卷号 | 57期号:24页码:7131-7135 |
| 关键词 | Hybridization Chain-reaction Tetrahedral Dna Nanostructure Gold Nanoparticles Messenger-rna Electrochemical Detection Inorganic Nanomaterials Reaction Amplification Biomolecular Detection Biosensing Interface Gene-expression |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201802701 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Weak ligand-receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However, signal amplification in invitro biomimetic systems generally lack the spatiotemporal regulation invivo. Herein we report a framework nucleic acid (FNA)-programmed strategy to develop valence-controlled signal amplifiers with high modularity for ultrasensitive biosensing. We demonstrated that the FNA-programmed signal amplifiers could recruit nucleic acids, proteins, and inorganic nanoparticles in a stoichiometric manner. The valence-controlled signal amplifier enhanced the quantification ability of electrochemical biosensors, and enabled ultrasensitive detection of tumor-relevant circulating free DNA (cfDNA) with sensitivity enhancement of 3-5 orders of magnitude and improved dynamic range. |
| 语种 | 英语 |
| WOS记录号 | WOS:000434350400027 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/29206]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Liu, Q 2.Ge, ZL 3.Mao, XH 4.Zhou, GB 5.Zuo, XL 6.Shen, JW 7.Shi, JY 8.Li, J 9.Wang, LH 10.Chen, XQ |
| 推荐引用方式 GB/T 7714 | Liu, Q,Ge, ZL,Mao, XH,et al. Valency-Controlled Framework Nucleic Acid Signal Amplifiers[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(24):7131-7135. |
| APA | Liu, Q.,Ge, ZL.,Mao, XH.,Zhou, GB.,Zuo, XL.,...&Fan, CH.(2018).Valency-Controlled Framework Nucleic Acid Signal Amplifiers.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(24),7131-7135. |
| MLA | Liu, Q,et al."Valency-Controlled Framework Nucleic Acid Signal Amplifiers".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.24(2018):7131-7135. |
入库方式： OAI收割
来源：上海应用物理研究所
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