Biocompatibility assay of cellular behavior inside a leaf-inspired biomimetic microdevice at the single-cell level
文献类型：期刊论文
| 作者 | Wu, W. M. and A. Manz |
| 刊名 | Rsc Advances
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:52 |
| 英文摘要 | Herein, we introduce a practical and effective manufacturing methodology for a biomimetic microdevice replicated from the Tilia platyphyllos leaf. With this method, artificial microchambers (of controllable dimension and depth) can be easily integrated into leaf-inspired whole-ordered venation patterns. To display the biocompatibility of this microdevice, we applied it to a long-term (seven days) cell culture and monitored the results. Based on a comprehensive biophysical analysis, including covering cellular deformation, cell migration, cytomembrane tension, extracellular communication, protonema formation, microvilli, and the tethers' dynamic of human melanoma cells inside the device at a single-cell resolution, we were able to verify for the first time a leaf-inspired PDMS microdevice as a biocompatible platform for mammal cell culture, showing promise that such a biomimetic device could be further applied for organ-on-a-chip studies and other biomedical research. |
| 语种 | 英语 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/59323]  |
| 专题 | 长春光学精密机械与物理研究所_中科院长春光机所知识产出 |
| 推荐引用方式 GB/T 7714 | Wu, W. M. and A. Manz. Biocompatibility assay of cellular behavior inside a leaf-inspired biomimetic microdevice at the single-cell level[J]. Rsc Advances,2017,7(52). |
| APA | Wu, W. M. and A. Manz.(2017).Biocompatibility assay of cellular behavior inside a leaf-inspired biomimetic microdevice at the single-cell level.Rsc Advances,7(52). |
| MLA | Wu, W. M. and A. Manz."Biocompatibility assay of cellular behavior inside a leaf-inspired biomimetic microdevice at the single-cell level".Rsc Advances 7.52(2017). |
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