Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds.
文献类型：期刊论文
| 作者 | Wang, Daming; Liu, Wei; Feng, Qian; Dong, Chaoqun; Liu, Qisong; Duan, Li; Huang, Jianghong; Zhu, Weimin; Li, Zemeng; Xiong, Jianyi |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Inorganic/organic hybrid scaffolds have great potential for tissue engineering applications due to controllable mechanical properties and tailorable biodegradation. Here, silica/chitosan hybrid scaffolds were fabricated through the sol-gel method with a freeze drying process. 3-Glycidoxypropyl trimethoxysilane (GPTMS) and tetraethylorthosilicate (TEOS) were used as the covalent inorganic/organic coupling agent and the separate inorganic source, respectively. Hybrid scaffolds with various inorganic/organic weight ratios (I/Os) and molar ratios of chitosan and GPTMS (GCs) were examined and compared in this study. FTIR showed that higher GPTMS content resulted in the increased covalent cross-linking of the chitosan and the silica network in hybrids. Compression testing indicated that increasing the GPTMS content greatly improved the compressive strength of scaffold. LIVE/DEAD assay showed that enhanced cytocompatibility was obtained as the silica content increased. Therefore, the results confirmed that the two parameters I/O and GC can largely influence the scaffold performance, which can be used to tailor the hybrid properties. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11662]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS |
| 推荐引用方式 GB/T 7714 | Wang, Daming,Liu, Wei,Feng, Qian,et al. Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds.[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017. |
| APA | Wang, Daming.,Liu, Wei.,Feng, Qian.,Dong, Chaoqun.,Liu, Qisong.,...&Wang, Daping.(2017).Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds..MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. |
| MLA | Wang, Daming,et al."Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds.".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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