Changed hub and corresponding functional connectivity of subgenual anterior cingulate cortex in major depressive disorder
文献类型：期刊论文
| 作者 | Huawang Wu; Hui Sun; Jinping Xu; Yan Wu; Chao Wang; Jing Xiao; Shenglin She; Jianwei Huang; Wenjin Zou; Hongjun Peng |
| 刊名 | Frontiers in Neuroanatomy
 |
| 出版日期 | 2016 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Major depressive disorder (MDD) is one of the most prevalent mental disorders. In the brain, the hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset ofMDD remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations ofhubs can be detected in MDD. First, we constructed the whole-brain voxel-wise functional networks and calculated a functional connectivity strength (FCS) map in each subject in 34 MDD patients and 34 gender-, age- and education level-matched healthy controls (HCs). Next, the two-sample t-test was applied to compare the FCS maps between HC and MDD patients and identified significant decrease of FCS in subgenual anterior cingulate cortex (sgACC) in MDD patients. Subsequent functional connectivity analyses of sgACC showed disruptions in functional connectivity with posterior insula, middle and inferior temporal gyrus, lingual gyrus and cerebellum in MDD patients. Furthermore, the changed FCS of sgACC and functional connections to sgACC were significantly correlated with the Hamilton Depression Rating Scale (HDRS) scores in MDD patients. The results of the present study revealed the abnormal hub of sgACC and its corresponding disrupted frontal limbic -visual cognitive-cerebellum functional networks in MDD. These findings may provide a new insight for the diagnosis and treatment of MDD. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11956]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Frontiers in Neuroanatomy |
| 推荐引用方式 GB/T 7714 | Huawang Wu,Hui Sun,Jinping Xu,et al. Changed hub and corresponding functional connectivity of subgenual anterior cingulate cortex in major depressive disorder[J]. Frontiers in Neuroanatomy,2016. |
| APA | Huawang Wu.,Hui Sun.,Jinping Xu.,Yan Wu.,Chao Wang.,...&Jiaojian Wang.(2016).Changed hub and corresponding functional connectivity of subgenual anterior cingulate cortex in major depressive disorder.Frontiers in Neuroanatomy. |
| MLA | Huawang Wu,et al."Changed hub and corresponding functional connectivity of subgenual anterior cingulate cortex in major depressive disorder".Frontiers in Neuroanatomy (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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