Abnormalities in Structural Covariance of Cortical Gyrification in Parkinson's Disease.
文献类型：期刊论文
| 作者 | Xu, Jinping; Zhang, Jiuquan; Zhang, Jinlei; Wang, Yue; Zhang, Yanling; Wang, Jian; Li, Guanglin; Hu, Qingmao; Zhang, Yuanchao |
| 刊名 | FRONTIERS IN NEUROANATOMY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Although abnormal cortical morphology and connectivity between brain regions (structural covariance) have been reported in Parkinson's disease (PD), the topological organizations of large-scale structural brain networks are still poorly understood. In this study, we investigated large-scale structural brain networks in a sample of 37 PD patients and 34 healthy controls (HC) by assessing the structural covariance of cortical gyrification with local gyrification index (IGI). We demonstrated prominent small-world properties of the structural brain networks for both groups. Compared with the HC group, PD patients showed significantly increased integrated characteristic path length and integrated clustering coefficient, as well as decreased integrated global efficiency in structural brain networks. Distinct distributions of hub regions were identified between the two groups, showing more hub regions in the frontal cortex in PD patients. Moreover, the modular analyses revealed significantly decreased integrated regional efficiency in lateral Fronto-Insula-Temporal module, and increased integrated regional efficiency in Parieto-Temporal module in the PD group as compared to the HC group. In summary, our study demonstrated altered topological properties of structural networks at a global, regional and modular level in PD patients. These findings suggests that the structural networks of PD patients have a suboptimal topological organization, resulting in less effective integration of information between brain regions. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11957]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | FRONTIERS IN NEUROANATOMY |
| 推荐引用方式 GB/T 7714 | Xu, Jinping,Zhang, Jiuquan,Zhang, Jinlei,et al. Abnormalities in Structural Covariance of Cortical Gyrification in Parkinson's Disease.[J]. FRONTIERS IN NEUROANATOMY,2017. |
| APA | Xu, Jinping.,Zhang, Jiuquan.,Zhang, Jinlei.,Wang, Yue.,Zhang, Yanling.,...&Zhang, Yuanchao.(2017).Abnormalities in Structural Covariance of Cortical Gyrification in Parkinson's Disease..FRONTIERS IN NEUROANATOMY. |
| MLA | Xu, Jinping,et al."Abnormalities in Structural Covariance of Cortical Gyrification in Parkinson's Disease.".FRONTIERS IN NEUROANATOMY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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