Abnormal cortical-basal ganglia network in amyotrophic lateral sclerosis: A voxel-wise network efficiency analysis.
文献类型：期刊论文
| 作者 | Xu, Jinping ; Li, Hong ; Li, Chong ; Yao, Jen-Chih ; Hu, Jun ; Wang, Jian ; Hu, Qingmao ; Zhang, Yuanchao ; Zhang, Jiuquan |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Evidence suggests that dysfunctional cortical-basal ganglia (CBG) network plays important roles in the motor symptoms in amyotrophic lateral sclerosis (ALS). However, little effort has been made to investigate the functional abnormalities of CBG network in ALS. Here, we constructed voxel-wise CBG networks using the resting state fMRI data of 20 patients with ALS and 21 normal controls, and characterized the differences of their efficiency parameters between the two groups. Compared to normal controls, patients with ALS exhibited decreased nodal efficiency in the right thalamus (THA), the left caudate (CAU) and the right precentral gyms (preCG), and increased nodal efficiency in the left preCG. In the patient group, we observed a significant negative correlation between the nodal efficiency of the right preCG and disease progression rate. These results demonstrate that both ineffective information transfer and compensatory mechanisms are involved in the pathophysiological mechanism underlying the motor dysfunctions in patients with ALS. In summary, the present study provides a novel perspective on pathophysiological explanation for the motor symptoms in patients with ALS. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11966]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | BEHAVIOURAL BRAIN RESEARCH |
| 推荐引用方式 GB/T 7714 | Xu, Jinping , Li, Hong , Li, Chong ,et al. Abnormal cortical-basal ganglia network in amyotrophic lateral sclerosis: A voxel-wise network efficiency analysis.[J]. BEHAVIOURAL BRAIN RESEARCH,2017. |
| APA | Xu, Jinping ., Li, Hong ., Li, Chong ., Yao, Jen-Chih ., Hu, Jun .,...& Zhang, Jiuquan.(2017).Abnormal cortical-basal ganglia network in amyotrophic lateral sclerosis: A voxel-wise network efficiency analysis..BEHAVIOURAL BRAIN RESEARCH. |
| MLA | Xu, Jinping ,et al."Abnormal cortical-basal ganglia network in amyotrophic lateral sclerosis: A voxel-wise network efficiency analysis.".BEHAVIOURAL BRAIN RESEARCH (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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