Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method.
文献类型：期刊论文
| 作者 | Zhang, Guanglei; Liu, Fei; Liu, Jie; Luo, Jianwen; Xie, Yaoqin; Bai, Jing; Xing, Lei |
| 刊名 | IEEE TRANSACTIONS ON MEDICAL IMAGING
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | X-ray luminescence computed tomography (XLCT), which aims to achieve molecular and functional imaging by X-rays, has recently been proposed as a new imaging modality. Combining the principles of X-ray excitation of luminescence-based probes and optical signal detection, XLCT naturally fuses functional and anatomical images and provides complementary information for a wide range of applications in biomedical research. In order to improve the data acquisition efficiency of previously developed narrow-beam XLCT, a cone beam XLCT (CB-XLCT) mode is adopted here to take advantage of the useful geometric features of cone beam excitation. Practically, a major hurdle in using cone beam X-ray for XLCT is that the inverse problem here is seriously ill-conditioned, hindering us to achieve good image quality. In this paper, we propose a novel Bayesian method to tackle the bottleneck in CB-XLCT reconstruction. The method utilizes a local regularization strategy based on Gaussian Markov random field to mitigate the ill-conditioness of CB-XLCT. An alternating optimization scheme is then used to automatically calculate all the unknown hyperparameters while an iterative coordinate descentalgorithm is adopted to reconstruct the image with a voxel-based closed-formsolution. Results of numerical simulations and mouse experiments show that the self-adaptive Bayesian methodsignificantly improves the CB-XLCT image quality as compared with conventional methods. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11971]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | IEEE TRANSACTIONS ON MEDICAL IMAGING |
| 推荐引用方式 GB/T 7714 | Zhang, Guanglei,Liu, Fei,Liu, Jie,et al. Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method.[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2017. |
| APA | Zhang, Guanglei.,Liu, Fei.,Liu, Jie.,Luo, Jianwen.,Xie, Yaoqin.,...&Xing, Lei.(2017).Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method..IEEE TRANSACTIONS ON MEDICAL IMAGING. |
| MLA | Zhang, Guanglei,et al."Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method.".IEEE TRANSACTIONS ON MEDICAL IMAGING (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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