A Fully-Automatic Multiparametric Radiomics Model: Towards Reproducible and Prognostic Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme.
文献类型：期刊论文
| 作者 | Li, Qihua ; Bai, Hongmin ; Chen, Yinsheng ; Sun, Qiuchang ; Liu, Lei ; Zhou, Sijie ; Wang, Guoliang ; Liang, Chaofeng ; Li, Zhi-Cheng |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In fully-automatic radiomics model for predicting overall survival (OS) of glioblastoma multiforme (GBM) patients, the effect of image standardization parameters such as voxel size, quantization method and gray level on model reproducibility and prognostic performance are still unclear. In this study, 45792 multiregional radiomics features were automatically extracted from multi-modality MR images with different voxel sizes, quantization methods, and gray levels. The feature reproducibility and prognostic performance were assessed. Multiparametric and fixed-parameter radiomics signatures were constructed based on atraining cohort (60 patients). In an independent validation cohort (32 patients), the multiparametric signature achieved better performance for OS prediction (C-Index = 0.705, 95% CI: 0.672, 0.738) and significant stratification of patients into high-and low-risk groups (P = 0.0040, HR = 3.29, 95% CI: 1.40, 7.70), which outperformed the fixed-parameter signatures and conventional factors such as age, Karnofsky Performance Score and tumor volume. This study demonstrated that voxel size, quantization method and gray level had influence on reproducibility and prognosis of radiomics features for GBM OS prediction. An automatic method to determine the optimal parameter settings was provided. It indicated that multiparametric radiomics signature had the potential of offering better prognostic performance than fixed-parameter signatures. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12004]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Li, Qihua , Bai, Hongmin , Chen, Yinsheng ,et al. A Fully-Automatic Multiparametric Radiomics Model: Towards Reproducible and Prognostic Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme.[J]. SCIENTIFIC REPORTS,2017. |
| APA | Li, Qihua ., Bai, Hongmin ., Chen, Yinsheng ., Sun, Qiuchang ., Liu, Lei .,...& Li, Zhi-Cheng.(2017).A Fully-Automatic Multiparametric Radiomics Model: Towards Reproducible and Prognostic Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme..SCIENTIFIC REPORTS. |
| MLA | Li, Qihua ,et al."A Fully-Automatic Multiparametric Radiomics Model: Towards Reproducible and Prognostic Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme.".SCIENTIFIC REPORTS (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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