N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo
文献类型：期刊论文
| 作者 | Min Chen; Yang Xu; Rongchen Huang; Yubin Huang; Shuchao Ge; Bing Hu |
| 刊名 | Molecular Neurobiology
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Stimulating neuronal activity increases myelin of myelinating capacity of zebrafish individual oligodendrocytes in vivo. sheath formation by individual oligodendrocytes, but how myelination is regulated by neuronal activity in vivo is still not fully understood. While in vitro studies have revealed the important role of N-cadherin in myelination, our understanding in vivo remains quite limited. To obtain the role of Ncadherin during activity-dependent regulation of myelinating capacity of individual oligodendrocytes, we successfully built an in vivo dynamic imaging model of the Mauthner cell at the subcellular structure level in the zebrafish central nervous system. Enhanced green fluorescent protein (EGFP)-tagged Ncadherin was used to visualize the stable accumulations and mobile transports of N-cadherin by single-cell electroporation at the single-cell level.We found that pentylenetetrazol (PTZ) significantly enhanced the accumulation of N-cadherin in Mauthner axons, a response that was paralleled by enhanced sheath number per oligodendrocytes. By offsetting this phenotype using oligopeptide (AHAVD) which blocks the function of N-cadherin, we showed that PTZ regulates myelination in an N-cadherin-dependent manner. What is more, we further suggested that PTZ influencesN-cadherin and myelination via a cAMP pathway. Consequently, our data indicated that Ncadherin is involved in neuronal activity-dependent regulation |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12031]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Molecular Neurobiology |
| 推荐引用方式 GB/T 7714 | Min Chen,Yang Xu,Rongchen Huang,et al. N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo[J]. Molecular Neurobiology,2017. |
| APA | Min Chen,Yang Xu,Rongchen Huang,Yubin Huang,Shuchao Ge,&Bing Hu.(2017).N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo.Molecular Neurobiology. |
| MLA | Min Chen,et al."N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo".Molecular Neurobiology (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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