Superhydrophobic silica nanoparticles as ultrasound contrast agents.
文献类型：期刊论文
| 作者 | Yang, Chia-Min; Kang, Shih-Tsung; Lin, Chih-Yu; Chang, Yuan-Chih; Zheng, Hairong |
| 刊名 | ULTRASONICS SONOCHEMISTRY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Microbubbles have been widely studied as ultrasound contrast agents for diagnosis and as drug/gene carriers for therapy. However, their size and stability (lifetime of 5-12 min) limited their applications. The development of stable nanoscale ultrasound contrast agents would therefore benefit both. Generating bubbles persistently in situ would be one of the promising solutions to the problem of short lifetime. We hypothesized that bubbles could be generated in situ by providing stable air nuclei since it has been found that the interfacial nanobubbles on a hydrophobic surface have a much longer lifetime (orders of days). Mesoporous silica nanoparticles (MSNs) with large surface areas and different levels of hydrophobicity were prepared to test our hypothesis. It is clear that the superhydrophobic and porous nanoparticles exhibited a significant and strong contrast intensity compared with other nanoparticles. The bubbles generated from superhydrophobic nanoparticles sustained for at least 30 min at a MI of 1.0, while lipid microbubble lasted for about 5 min at the same settings. In summary MSNs have been transformed into reliable bubble precursors by making simple superhydrophobic modification, and made into a promising contrast agent with the potentials to serve as theranostic agents that are sensitive to ultrasound stimulation. (C) 2016 Elsevier B.V. All rights reserved. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12050]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | ULTRASONICS SONOCHEMISTRY |
| 推荐引用方式 GB/T 7714 | Yang, Chia-Min,Kang, Shih-Tsung,Lin, Chih-Yu,et al. Superhydrophobic silica nanoparticles as ultrasound contrast agents.[J]. ULTRASONICS SONOCHEMISTRY,2017. |
| APA | Yang, Chia-Min,Kang, Shih-Tsung,Lin, Chih-Yu,Chang, Yuan-Chih,&Zheng, Hairong.(2017).Superhydrophobic silica nanoparticles as ultrasound contrast agents..ULTRASONICS SONOCHEMISTRY. |
| MLA | Yang, Chia-Min,et al."Superhydrophobic silica nanoparticles as ultrasound contrast agents.".ULTRASONICS SONOCHEMISTRY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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