Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves
文献类型：期刊论文
| 作者 | Wei Zhou; Jingjing Wang; Kaiyue wang; Bin Huang; Xin Liu; Lili Niu; Fei Li; Feiyan Cai; Yan Chen; Xiaoyan Zhang |
| 刊名 | Lab on a Chip
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Ultrasound neuro-modulation has gained increasing attention as a non-invasive method. In this paper, we present an ultrasound-neuromoduation chip, capable of initiating reversal behaviour and activating neurons of C. elegans under the stimulation of a single-shot, short-pulsed ultrasound. About 85.29%± 6.17% worms respond to the ultrasound stimulation exhibiting a reversal behaviour. Furthermore, the worms can adapt to the ultrasound stimulation with a lower acoustic pulse duration of stimulation. In vivo calcium imaging shows that the activity of ASH, a polymodal sensory neuron in C. elegans, can be directly evoked by the ultrasound stimulation. On the other hand, AFD, a thermal sensitive neuron, can not be activated by the ultrasound stimulation using the same parameter and the temperature elevation during the stimulation process is relatively small. Consistent with the calcium imaging results, the tax-4 mutants, which are insensitive to temperature increase, do not show a significant difference in avoidance probability compared to the wild type. Therefore, the mechanical effects induced by ultrasound are the main reason for neural and behavioural modulation of C. elegans. With the advantages of confined acoustic energy on the surface compatible with standard calcium imaging, this neuromodulation chip could be a powerful tool for revealing the molecular mechanisms of ultrasound neuro-modulation. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12062]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Lab on a Chip |
| 推荐引用方式 GB/T 7714 | Wei Zhou,Jingjing Wang,Kaiyue wang,et al. Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves[J]. Lab on a Chip,2017. |
| APA | Wei Zhou.,Jingjing Wang.,Kaiyue wang.,Bin Huang.,Xin Liu.,...&Hairong Zheng.(2017).Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves.Lab on a Chip. |
| MLA | Wei Zhou,et al."Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves".Lab on a Chip (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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