Preparation and characterization of a novel silicon-modified nanobubble.
文献类型：期刊论文
| 作者 | Zhang, Bo; Zhou, Meijun; Li, Fei; Huang, Xiuxian; Pan, Min; Xue, Li; Yan, Fei; Liu, Jia; Li, Maotong |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Nanobubbles (NBs) opened a new field of ultrasound imaging. There is still no practical method to control the diameter of bubbles. In this study, we developeda new method to control the size by incorporating of silicon hybrid lipids into the bubble membrane. The range of particle size of resulting NBs is between 523.02 +/- 46.45 to 857.18 +/- 82.90, smaller than the conventional microbubbles. The size of resulting NBs increased with the decrease in amount of silicon hybrid lipids, indicating the diameter of NBs can be regulated through modulating the ratio of silicon hybrid lipids in the bubble shell. Typical harmonic signals could be detected. The in vitro and in vivo ultrasound imaging experiments demonstrated these silicon-modified NBs had significantly improved ultrasound contrast enhancement abilities. Cytotoxicity assays revealed that these NBs had no obvious cytotoxicity to the 293 cell line at the tested bubble concentration. Our results showed that the novel NBs could use as nanoscale ultrasound contrast agents, providing the foundation for NBs in future applications including contrast- enhanced imaging and drug/gene delivery. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12067]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | PLOS ONE |
| 推荐引用方式 GB/T 7714 | Zhang, Bo,Zhou, Meijun,Li, Fei,et al. Preparation and characterization of a novel silicon-modified nanobubble.[J]. PLOS ONE,2017. |
| APA | Zhang, Bo.,Zhou, Meijun.,Li, Fei.,Huang, Xiuxian.,Pan, Min.,...&Li, Maotong.(2017).Preparation and characterization of a novel silicon-modified nanobubble..PLOS ONE. |
| MLA | Zhang, Bo,et al."Preparation and characterization of a novel silicon-modified nanobubble.".PLOS ONE (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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