Quantitative Analysis of Lipid-Rich Necrotic Core in Carotid Atherosclerotic Plaques by In Vivo Magnetic Resonance Imaging and Clinical Outcomes.
文献类型：期刊论文
| 作者 | Li, Zhenzhou; Liu, Xin; Xie, Ni; Peng, Xianghong; Xia, Jun; Yin, Anyu |
| 刊名 | MEDICAL SCIENCE MONITOR
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Background: The aim of this study was to explore the accuracy of in vivo magnetic resonance imaging (MRI) in the quantitative evaluation of lipid-rich necrotic core (LRNC) in carotid atherosclerotic plaques compared with histopathology, and to assess the association of LRNC size with cerebral ischemia symptoms. Material/Methods: Thirty patients were enrolled and 19 patients (16 men and 3 women) were analyzed. All the patients were submitted to MRI on a Siemens Avanto (1.5-Tesla) device before carotid endarterectomy (CEA). The scanning protocol included three-dimensional time of flight (3D TOF), T-1-weighted image (T1WI), T-2-weighted image (T2WI), turbo spin-echo T-2-weighted (T-2-TSE), and contrast-enhanced T-1-weighted image. MRI images were reviewed for quantitative measurements of LRNC areas. LRNC specimens were collected for histology. Percentages of LRNC area to total vessel area were assessed to determine the association of MRI with histological findings. Results: There were 151 pairs of matched MRI and pathological sections. LRNC area percentages (LRNC area/vessel area) measured by MRI and histology were 20.6 +/- 9.0% and 18.7 +/- 9.5%, respectively (r=0.69, p<0.001). Twelve out of 19 patients had symptoms (S-group; 3 had recent stroke, 3 had a recent stroke and a history of transient ischemic attack (TIA), and 6 had TIA); the remaining 7 subjects showed no symptoms (NS-group). LRNC area percentages in the S-and NS-groups were 22.2 +/- 5.8% and 12.6 +/- 10.7%, respectively (p<0.05). |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12068]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | MEDICAL SCIENCE MONITOR |
| 推荐引用方式 GB/T 7714 | Li, Zhenzhou,Liu, Xin,Xie, Ni,et al. Quantitative Analysis of Lipid-Rich Necrotic Core in Carotid Atherosclerotic Plaques by In Vivo Magnetic Resonance Imaging and Clinical Outcomes.[J]. MEDICAL SCIENCE MONITOR,2017. |
| APA | Li, Zhenzhou,Liu, Xin,Xie, Ni,Peng, Xianghong,Xia, Jun,&Yin, Anyu.(2017).Quantitative Analysis of Lipid-Rich Necrotic Core in Carotid Atherosclerotic Plaques by In Vivo Magnetic Resonance Imaging and Clinical Outcomes..MEDICAL SCIENCE MONITOR. |
| MLA | Li, Zhenzhou,et al."Quantitative Analysis of Lipid-Rich Necrotic Core in Carotid Atherosclerotic Plaques by In Vivo Magnetic Resonance Imaging and Clinical Outcomes.".MEDICAL SCIENCE MONITOR (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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