pH imaging reveals worsened tissue acidification in diffusion kurtosis lesion than the kurtosis/diffusion lesion mismatch in an animal model of acute stroke.
文献类型：期刊论文
| 作者 | Wang, Enfeng ; Wu, Yin ; Cheung, Jerry S. ; Zhou, Iris Yuwen ; Igarashi, Takahiro ; Zhang, XiaoAn ; Sun, Phillip Zhe |
| 刊名 | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Diffusion weighted imaging (DWI) has been commonly used in acute stroke examination, yet a portion of DWI lesion may be salvageable. Recently, it has been shown that diffusion kurtosis imaging (DKI) defines the most severely damaged DWI lesion that does not renormalize following early reperfusion. We postulated that the diffusion and kurtosis lesion mismatch experience heterogeneous hemodynamic and/or metabolic injury. We investigated tissue perfusion, pH, diffusion, kurtosis and relaxation from regions of the contralateral normal area, diffusion lesion, kurtosis lesion and their mismatch in an animal model ofacute stroke. Our study revealed significant kurtosis and diffusion lesion volume mismatch (19.7 +/- 10.7%, P < 0.01). Although there was no significant difference in perfusion and diffusion between the kurtosis lesion and kurtosis/diffusion lesion mismatch, we showed lower pH in the kurtosis lesion (pH=6.64 +/- 0.12) from that of the kurtosis/diffusion lesion mismatch (6.84 +/- 0.11, P < 0.05). Moreover, pH in the kurtosis lesion and kurtosis/diffusion mismatch agreed well with literature values for regions of ischemic core and penumbra, respectively. Our work documented initial evidence that DKI may reveal theheterogeneous metabolic derangement within the commonly used DWI lesion. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12090]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM |
| 推荐引用方式 GB/T 7714 | Wang, Enfeng , Wu, Yin , Cheung, Jerry S. ,et al. pH imaging reveals worsened tissue acidification in diffusion kurtosis lesion than the kurtosis/diffusion lesion mismatch in an animal model of acute stroke.[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2017. |
| APA | Wang, Enfeng ., Wu, Yin ., Cheung, Jerry S. ., Zhou, Iris Yuwen ., Igarashi, Takahiro .,...& Sun, Phillip Zhe.(2017).pH imaging reveals worsened tissue acidification in diffusion kurtosis lesion than the kurtosis/diffusion lesion mismatch in an animal model of acute stroke..JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. |
| MLA | Wang, Enfeng ,et al."pH imaging reveals worsened tissue acidification in diffusion kurtosis lesion than the kurtosis/diffusion lesion mismatch in an animal model of acute stroke.".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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