Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics.
文献类型：期刊论文
| 作者 | Guo, Bing ; Sheng, Zonghai ; Hu, Dehong ; Li, Anran ; Xu, Shidang ; Manghnani, Purnima Naresh ; Liu, Chengbo ; Guo, Lin ; Zheng, Hairong ; Liu, Bin |
| 刊名 | ACS NANO
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Conjugated polymer nanoparticles (CP NPs) are emerging candidates of "all-in-one" theranostic nanoplat-forms with dual photoacoustic imaging (PA) and photothermal therapy (PTT) functions. So far, very limited molecular design guidelines have been developed for achieving CPs with highly efficient PA and PTT performance. Herein, by designing CP1, CP2, and CP3 using different electron acceptors (A) and a planar electron donor (D), we demonstrate how the D A strength affects their absorption, emission, extinction coefficient, and ultimately PA and PTT performance. The resultant CP NPs have strong PA signals with high photo thermal conversion efficiencies and excellent biocompatibility in vitro and in vivo. The CP3 NPs show a high PA signal to background ratio of 47 in U87 tumor-bearing mice, which is superior to other reported PA/PTT theranostic agents. A very small IC50 value of 0.88 mu g/mL (CP3 NPs) was obtained for U87 glioma cell ablation under laser irradiation (808 nm, 0.8 W/cm(2), 5 min). This study shows that CP NP based theranostic platforms are promising for future personalized nanomedicine. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12099]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | ACS NANO |
| 推荐引用方式 GB/T 7714 | Guo, Bing , Sheng, Zonghai , Hu, Dehong ,et al. Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics.[J]. ACS NANO,2017. |
| APA | Guo, Bing ., Sheng, Zonghai ., Hu, Dehong ., Li, Anran ., Xu, Shidang .,...& Liu, Bin.(2017).Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics..ACS NANO. |
| MLA | Guo, Bing ,et al."Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics.".ACS NANO (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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