Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma
文献类型：期刊论文
| 作者 | Mingting Zhu; Zonghai Sheng; Yali Jia; Dehong Hu; Xin Liu; Xianyuan Xia; Chengbo Liu; Pan Wang; Xiaobing Wang; and Hairong Zheng |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Active-targeted cancer imaging and therapy of glioma has attracted much attention in theranostic nanomedicine. As a promising tumor-targeting ligand, holotransferrin (holo-Tf) has been applied for enhancing delivery of nanotheranostics. However, holo-Tf-based nanoassemblies for active targeting mediated multimodal imaging and therapeutics have not been previously reported. Here, we develop a one-step method for the preparation of holo-Tf-indocyaninegreen (holo-Tf-ICG) nanoassemblies for fluorescence (FL) and photoacoustic (PA) dual-modal imaging and photothermal therapy (PTT) of glioma. The nanoassemblies are formed by hydrophobic interaction and hydrogen bonds between holo-Tf and ICG, which exhibit excellent active tumor-targeting and high biocompability. The brain tumor with highly expressed Tf receptor can be clearly observed with holo-Tf-ICG nanoassemblies base on FL and PA dual-modalimaging in subcutaneous and orthotopic glioma models. Under the near-infrared laser irradiation, the holo-Tf-ICG nanoassemblies accumulated in tumor regions can efficiently convert laser energy into hyperthermia for tumor ablation. The novel theranostic nanoplatform holds great promise for precision diagnosis and treatment of glioma. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12106]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | ACS APPLIED MATERIALS & INTERFACES |
| 推荐引用方式 GB/T 7714 | Mingting Zhu,Zonghai Sheng,Yali Jia,et al. Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma[J]. ACS APPLIED MATERIALS & INTERFACES,2017. |
| APA | Mingting Zhu.,Zonghai Sheng.,Yali Jia.,Dehong Hu.,Xin Liu.,...&and Hairong Zheng.(2017).Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma.ACS APPLIED MATERIALS & INTERFACES. |
| MLA | Mingting Zhu,et al."Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma".ACS APPLIED MATERIALS & INTERFACES (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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