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Porous composite scaffold incorporating osteogenic phytomolecule Icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits
文献类型：期刊论文
| 作者 | Yuxiao Lai; Huijuan Cao; Xinluan Wang; Shukui Chen; Ming Zhang; Nan Wang; Zhihong Yao; Yi Dai; Xinhui Xie; Peng Zhang |
| 刊名 | Biomaterials
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Steroid-associated osteonecrosis (SAON) often requires surgical core decompression (CD) in the early stage for removal of necrotic bone to facilitate repair where bone grafts are needed for filling bone defect and avoiding subsequent joint collapse. In this study, we developed a bioactive composite scaffold incorporated with icariin, a unique phytomolecule that can provide structural and mechanical support and facilitate bone regeneration to fill into bone defects after surgical CD in established SAON rabbit model. An innovative low-temperature 3D printing technology was used to fabricate the poly (lactic-co-glycolic acid)/β-calcium phosphate/icariin (PLGA/TCP/Icariin, PTI) scaffold. The cytocompatibility of the PTI scaffold was testedin vitro, and the osteogenesis properties of PTI scaffolds were assessed in vivo in the SAON rabbit models. Our results showed that the fabricated PTI scaffold had a well-designed biomimic structure that was precisely printed to provide increased mechanical support and stable icariin release from the scaffold for bone regeneration. Furthermore, our in vivo study indicated that the PTI scaffold could enhanced the mechanical properties of new bone tissues and improved angiogenesis within the implanted region in SAON rabbit model than those of PLGA/TCP (PT) scaffold. The underlying osteoblastic mechanism was investigated using MC3T3-E1 cells in vitro and revealed that icariin could facilitate MC3T3-E1 cells ingrowth into the PTI scaffold and regulate osteoblastic differentiation. The PTI scaffold exhibited superior biodegradability, biocompatibility, and osteogenic capability compared with those of PT scaffold. In summary, the PTI composite scaffold which incorporated bioactive phyto-compounds is a promising potential strategy for bone tissue engineering and regeneration in patients with challenging SAON. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000418223800001 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12155]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Biomaterials |
| 推荐引用方式 GB/T 7714 | Yuxiao Lai,Huijuan Cao,Xinluan Wang,et al. Porous composite scaffold incorporating osteogenic phytomolecule Icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits[J]. Biomaterials,2018. |
| APA | Yuxiao Lai.,Huijuan Cao.,Xinluan Wang.,Shukui Chen.,Ming Zhang.,...&Ling Qin.(2018).Porous composite scaffold incorporating osteogenic phytomolecule Icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits.Biomaterials. |
| MLA | Yuxiao Lai,et al."Porous composite scaffold incorporating osteogenic phytomolecule Icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits".Biomaterials (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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