Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review
文献类型：期刊论文
| 作者 | Long Li; Ming Zhang; Ye Li; Jie Zhao; Ling Qin; Yuxiao Lai |
| 刊名 | Regenerative Biomaterials
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Magnesium (Mg) or its alloys are widely tested as potential orthopedic implants, particularly as biodegradable alloys for fracture fixation due to their mechanical properties are close to those of bone. Currently, available Mg or its alloys are confronted with challenges in passing regulatory biosafety tests prior to clinical trials due to its fast degradation and associated degradation products. The degradation of Mg is accompanied by the release of Mg ions, the rise of pH and osmolality in surrounding environments. According to the standard of ISO 10993 Part 13, the pH value shall be appropriate to the site of intended use maintaining in an appropriate range. Approaches to overcome these challenges include the selection of adequate alloying elements, proper surface treatment techniques and control of the degradation rate of Mg or its alloys developed as orthopedic implants. To date, Mg or its alloy-based bone implants have not yet been widely used in clinical applications as medical implants. This review critically summarized published methods to improve the corrosion resistance of Mg and its alloys. The current progress on in vitro cytotoxicity and in vivo biocompatibility properties of these metals was also reviewed. This review aimed to provide a reference for further research and development (R&D) of biodegradable Mg and its alloys with regard to the evaluation of their corrosion process and biocompatibility and facilitation of their translation to clinical applications |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12156]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | Regenerative Biomaterials |
| 推荐引用方式 GB/T 7714 | Long Li,Ming Zhang,Ye Li,et al. Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review[J]. Regenerative Biomaterials,2017. |
| APA | Long Li,Ming Zhang,Ye Li,Jie Zhao,Ling Qin,&Yuxiao Lai.(2017).Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review.Regenerative Biomaterials. |
| MLA | Long Li,et al."Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review".Regenerative Biomaterials (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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