Synthesis and structure-activity relationship studies of teixobactin analogues.
文献类型：期刊论文
| 作者 | Wu, Chunlei; Pan, Zhengyin; Su, Wu; Yao, Guiyang; Wang, Wei; Fang, Lijing |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | A new series of teixobactin analogues were synthesized via an oxidative cyclative cleavage approach using aryl hydrazide resin as the solid support. Structure-activity relationship studies revealed that the guanidine or amine group at position 10, the hydroxyl group of Ser(7) residue and the NH proton of the N-terminal Phe(1) residue are critical to the antibacterial activities, while side chain size and functional group changes are tolerated at position 4. These findings will facilitate the development of new teixobactin analogues with enhanced pharmacological properties. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12251]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | RSC ADVANCES |
| 推荐引用方式 GB/T 7714 | Wu, Chunlei,Pan, Zhengyin,Su, Wu,et al. Synthesis and structure-activity relationship studies of teixobactin analogues.[J]. RSC ADVANCES,2017. |
| APA | Wu, Chunlei,Pan, Zhengyin,Su, Wu,Yao, Guiyang,Wang, Wei,&Fang, Lijing.(2017).Synthesis and structure-activity relationship studies of teixobactin analogues..RSC ADVANCES. |
| MLA | Wu, Chunlei,et al."Synthesis and structure-activity relationship studies of teixobactin analogues.".RSC ADVANCES (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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