Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy.
文献类型：期刊论文
| 作者 | Hu, Dehong; Cai, Lintao; Ling, Shaozhi; Zhang, Pengfei; Wu, Yayun; Gao, Guanhui; Yi, Huqiang; Sheng, Zonghai; Liu, Peng; Ding, Zexuan |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe3O4 NPs) by loading Fe3O4 nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe3O4 NPs demonstrated a uniform nanospherical morphology consisting of Fe3O4 clusters. The fluorescence signal of Ce6 of this theranostic system could turn "ON" from a self-quenching state in a reductive intracellular environment. T-2-Weighted MR imaging revealed a high transverse relaxivity (r(2)) measured to be 194.4 S-1 mM(-1), confirming that it was also a distinctive contrast agent in T-2-weighted MR imaging. Confocal images and flow cytometry results showed that the cellular uptake of DSSCe6@Fe3O4 NPs was enhanced effectively under an extra magnetic field, which resulted in promoted PDT therapeutic efficiency. In vivo MR imaging showed that DSSCe6@Fe3O4 NPs effectively accumulated in tumors under an extra magnetic field. These results illustrated that the DSSCe6@Fe3O4 NPs could be a promising theranostic system for both NIR/MR imaging-guided PDT precision therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12252]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMATERIALS SCIENCE |
| 推荐引用方式 GB/T 7714 | Hu, Dehong,Cai, Lintao,Ling, Shaozhi,et al. Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy.[J]. BIOMATERIALS SCIENCE,2017. |
| APA | Hu, Dehong.,Cai, Lintao.,Ling, Shaozhi.,Zhang, Pengfei.,Wu, Yayun.,...&Ding, Zexuan.(2017).Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy..BIOMATERIALS SCIENCE. |
| MLA | Hu, Dehong,et al."Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy.".BIOMATERIALS SCIENCE (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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