Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy
文献类型：期刊论文
| 作者 | Dapeng Ni; Xiaoqing Meng; Yueting Yang; Lihua Zhou; li Zhang; Yalin Lv; Sanpeng Li; Yayun Wu; Mingbin Zheng; Wenjun Li |
| 刊名 | Theranostics
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The precision oncology significantly relies on the development of multifunctional agents to integrate tumor targeting, imaging and therapeutics. In this study, a first small-molecule theranostic probe, RhoSSCy is constructed by conjugating 5′-carboxyrhodamines (Rho) and heptamethine cyanine IR765 (Cy) using a reducible disulfide linker and pH tunable amino-group to realize thiols/pH dual sensing. In vitro experiments verify that RhoSSCy is highly sensitive for quantitative analysis and imaging intracellular pH gradient and biothiols. Furthermore, RhoSSCy shows superb tumor targeted dual-modal imaging via near-infrared fluorescence (NIRF) and photoacoustic (PA). Importantly, RhoSSCy also induces strongly reactive oxygen species for tumor photodynamic therapy (PDT) with robust antitumor activity both in vitro and in vivo. Such versatile small-molecule theranostic probe may be promising for tumor targeted imaging and precision therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12255]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Theranostics |
| 推荐引用方式 GB/T 7714 | Dapeng Ni,Xiaoqing Meng,Yueting Yang,et al. Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy[J]. Theranostics,2017. |
| APA | Dapeng Ni.,Xiaoqing Meng.,Yueting Yang.,Lihua Zhou.,li Zhang.,...&Lintao Cai.(2017).Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy.Theranostics. |
| MLA | Dapeng Ni,et al."Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy".Theranostics (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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