Myristic acid-modified thymopentin for enhanced plasma stability and immune-modulating activity.
文献类型：期刊论文
| 作者 | Tan, Yuanyan; Wang, Wei; Wu, Chunlei; Pan, Zhengyin; Yao, Guiyang; Fang, Lijing; Su, Wu |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Natural albumin ligand (fatty acids)-conjugated peptides can rapidly bind to circulating albumin and form complexes to control the release of peptides. The purpose of this study was to prolong the half-life and immune-modulating effects of thymopentin (TP5) by using the albumin binding strategy. We synthesizedmyristic acid-modified TP5 (TP5-MA) by conjugating a myristic acid-acylated lysine to a permissive site of TP5, which improved the albumin binding affinity of TP5-MA and dramatically enhanced its stability in human plasma. We observed well-preserved bioactivities of TP5-MA in RAW264.7 macrophages using a tumor necrosis factor (TNF)-alpha stimulation assay. Moreover, the prolonged immune-modulating effect of TP5-MA was confirmed by the normalized CD4(+)/CD8(+) ratio in immune-depressed rat models, which resulted in a reduced administration frequency (twice per week). In general, the enhancedpharmacoldnetic and pharmacodynamic properties of TP5-MA make it a promising product for the treatment of immunodeficiency diseases. (C) 2017 Elsevier B.V. All rights reserved. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12260]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | INTERNATIONAL IMMUNOPHARMACOLOGY |
| 推荐引用方式 GB/T 7714 | Tan, Yuanyan,Wang, Wei,Wu, Chunlei,et al. Myristic acid-modified thymopentin for enhanced plasma stability and immune-modulating activity.[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2017. |
| APA | Tan, Yuanyan.,Wang, Wei.,Wu, Chunlei.,Pan, Zhengyin.,Yao, Guiyang.,...&Su, Wu.(2017).Myristic acid-modified thymopentin for enhanced plasma stability and immune-modulating activity..INTERNATIONAL IMMUNOPHARMACOLOGY. |
| MLA | Tan, Yuanyan,et al."Myristic acid-modified thymopentin for enhanced plasma stability and immune-modulating activity.".INTERNATIONAL IMMUNOPHARMACOLOGY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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