Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice.
文献类型：期刊论文
| 作者 | Zhou, Liang; Li, Huashun; Li, Hongchang; Zhu, Minyan; Hong, Yang; Qian, Wenyu |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Endocytic adaptor protein Numb is the first identified cell fate determinant in Drosophila melanogaster. It has been implicated in Notch signaling pathway and regulation of neural stem cells proliferation in the central nervous system. Numb is also expressed in postmitotic neurons, in vitro studies showed that Numb is involved in neuronal morphologic development, such as neurite growth, axonal growth and spine development. However, in vivo functions of Numb in the postmitotic neurons are largely unknown. Here we show that deletion of Numb/Numblike in glutamatergic neurons causes anxiety-like behavior in mouse. Inthis study, we conditionally deleted Numb and its homologous gene Numblike in the glutamatergic neurons in dorsal forebrain, and thoroughly characterized the behavioral phenotypes of mutant mice. On a battery of tests for anxiety-like behavior, the conditional double knockout mice showed increased anxiety-likebehavior on light/dark exploration and novel open field tests, but not on elevated zero maze tests. The conditional double knockout mice also displayed novelty induced hyperactivity in novel open field test. Control measures of general health, motor functions, startle response, sensorimotor gating, depression-related behaviors did not show differences between genotypes. Our present findings provide new insight into the indispensable functions of Numb/Numblike in the brain and behavior, and suggest that Numb/Numblike may play a role in mediating neuronal functions that underlie behaviors related to anxiety. (C) 2017 Published by Elsevier B.V. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12261]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BRAIN RESEARCH |
| 推荐引用方式 GB/T 7714 | Zhou, Liang,Li, Huashun,Li, Hongchang,et al. Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice.[J]. BRAIN RESEARCH,2017. |
| APA | Zhou, Liang,Li, Huashun,Li, Hongchang,Zhu, Minyan,Hong, Yang,&Qian, Wenyu.(2017).Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice..BRAIN RESEARCH. |
| MLA | Zhou, Liang,et al."Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice.".BRAIN RESEARCH (2017). |
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来源：深圳先进技术研究院
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