Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance
文献类型：期刊论文
| 作者 | Ruijing Liang; Aiqing Ma; Ze Chen; Mingbin Zheng; Lanlan Liu; Zhenyu Luo; Hao Tian; Zhiqun Han; Chengyu Lu; Lintao Cai |
| 刊名 | Advanced Functional Materials
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The inadequate oxygen supply in solid tumor causes hypoxia, which leads to drug resistance and poor chemotherapy outcomes. To solve this problem, a cancer cell membrane camouflaged nanocarrier is developed with a polymeric core encapsulating hemoglobin (Hb) and doxorubicin (DOX) for efficient chemotherapy. The designed nanoparticles (DHCNPs) retain the cancer cell adhesion molecules on the surface of nanoparticles for homologous targeting and possess the oxygen-carrying capacity of Hb for O2-interfered chemotherapy. The results show that DHCNPs not only achieve higher tumor specificity and lower toxicity by homologous targeting but also significantly reduce the exocytosis of DOX via suppressing the expressions of hypoxia-inducible factor-1α, multidrug resistance gene 1, and P-glycoprotein, thus resulting in safe and high-efficient chemotherapy. This work presents a new paradigm for targeted oxygen interference therapy by conquering hypoxia-involved therapeutic resistance and achieves effective treatment of solid tumors. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12264]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Advanced Functional Materials |
| 推荐引用方式 GB/T 7714 | Ruijing Liang,Aiqing Ma,Ze Chen,et al. Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance[J]. Advanced Functional Materials,2017. |
| APA | Ruijing Liang.,Aiqing Ma.,Ze Chen.,Mingbin Zheng.,Lanlan Liu.,...&Lintao Cai.(2017).Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance.Advanced Functional Materials. |
| MLA | Ruijing Liang,et al."Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance".Advanced Functional Materials (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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