Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B
文献类型：期刊论文
| 作者 | Guiyang Yao; Wu Su; Lijing Fang; Hongchang Li; Ke Liu; Zhehong Cheng; Wei Wang; Chunlei Wu; Zhengyin Pan |
| 刊名 | Organic Letters
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Gymnopeptides A and B are unprecedented highly N-methylated cyclic β-hairpin octadecapeptides with striking antiproliferative activities isolated from the mushroom Gymnopus fusipes. Using Fmoc-based solid-phase peptide synthesis, followed by macrolactamization of the resulting linear peptides, the first total synthesis of gymnopeptides A and B was successfully achieved in this study. The coupling methods used for the solid-phase synthesis and the cyclization were optimized, and the configuration of the Ser1/Thr1 residue in gymnopeptide A/B was determined to be l. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12266]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Organic Letters |
| 推荐引用方式 GB/T 7714 | Guiyang Yao,Wu Su,Lijing Fang,et al. Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B[J]. Organic Letters,2017. |
| APA | Guiyang Yao.,Wu Su.,Lijing Fang.,Hongchang Li.,Ke Liu.,...&Zhengyin Pan.(2017).Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B.Organic Letters. |
| MLA | Guiyang Yao,et al."Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B".Organic Letters (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。