Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response
文献类型：期刊论文
| 作者 | Ruijing Liang; Mubashir Hussain; Yujie Gao; Liping Liu; Ke Wang; Jun Li; Jun Xie; Guanxin Shen; Juan Tao; Jintao Zhu |
| 刊名 | Biomaterials
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | For nanovaccine-based cancer immunotherapy, dendritic cells (DCs) are one of the most powerful antigen presenting cells (APCs) that initiate and promote the maturation of antigen-specific cytotoxic T lymphocytes (e.g., CD8+ T cells) to induce the local and systemic antitumor immunity and further suppress the tumor metastasis and produce long-term protection against tumor. Thus, the activation and maturation of DCs is the prerequisite for efficient CD8+ T cell-based antitumor immune responses, which is considered as a primary and promising task for nanovaccine engineering. Herein, we introduce a versatile nanovaccine of liposomes-coated gold nanocages (Lipos-AuNCs) modified with DCs specific antibody aCD11c for targeted delivery of adjuvant MPLA and melanoma antigen peptide TRP2 to promote the activation and maturation of DCs, and enhance tumor specific T lymphocytes responses. Moreover, AuNCs accumulation and AuNCs-engulfed DCs migration to regional lymph node (RLN) became real-time visualization through in vivo fluorescence and photoacoustic (PA) imaging to monitor the immunity process. In vivo experimental results demonstrated that the targeted antigen/adjuvants-loaded AuNCs exhibited enhanced antitumor immune response to inhibit tumor growth and metastasis in both B16-F10 prophylactic and lung metastasis models, which may act as a promising nanoplatform for antitumor immunotherapy and in vivo tracking. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12271]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Biomaterials |
| 推荐引用方式 GB/T 7714 | Ruijing Liang,Mubashir Hussain,Yujie Gao,et al. Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response[J]. Biomaterials,2017. |
| APA | Ruijing Liang.,Mubashir Hussain.,Yujie Gao.,Liping Liu.,Ke Wang.,...&Jintao Zhu.(2017).Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response.Biomaterials. |
| MLA | Ruijing Liang,et al."Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response".Biomaterials (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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