Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation.
文献类型：期刊论文
| 作者 | Sun Zhihong; Li Wenjun; Zhang Jiali; Zhou Lihua; Deng Guanjun; Gong Ping; Cai Lintao; Meng Xiaoqing |
| 刊名 | Journal of Materials Chemistry B
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Near-infrared (NIR) organic dyes have received increasing attention in recent years as diagnostic and therapeutic agents in the field of tumor research. In this study, IR-822, a near-infrared fluorescence (NIRF) heptamethine cyanine dye, was chosen as a fluorophore due to its high extinction coefficients, and native preferential tumor accumulation property. To enhance its specificity in tumor imaging, N1-(pyridin-4- ylmethyl)ethane-1,2-diamine (PY) was conjugated to IR-822 as a pH-sensing receptor, forming a fluorophore–spacer–receptor molecular probe (IR-PY) that can modulate the fluorescence emission intensity through a fast photoinduced electron-transfer process, which allowed the probe to ‘‘switch on’’ significantly in an acidic tumor microenvironment and which realized enhanced NIRF imaging in vivo. Having a strong NIR absorption at 600–850 nm, this small-molecule IR-PY showed not only high spatial resolution photoacoustic (PA) imaging in mice, but also effective tumor photothermal ablation in vivo. After photothermal therapy (PTT) with IR-PY under NIR 808 nm laser irradiation, the mice exhibited remarkable ablation with no tumor recurrence after treatment. Therefore, a single smart small-molecule probe IR-PY has been designed, synthesized and verified as an ‘‘all in one’’ multifunctional agent, including pH sensitivity, tumor targeting, ‘‘switch-on’’ near-infrared fluorescence imaging, high-spatial-resolution PA imaging and efficient near-infrared photothermal therapy, which is promising for clinical application in NIRF/PA dual-modal imaging-guided cancer diagnosis and treatment. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12273]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Journal of Materials Chemistry B |
| 推荐引用方式 GB/T 7714 | Sun Zhihong,Li Wenjun,Zhang Jiali,et al. Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation.[J]. Journal of Materials Chemistry B,2017. |
| APA | Sun Zhihong.,Li Wenjun.,Zhang Jiali.,Zhou Lihua.,Deng Guanjun.,...&Meng Xiaoqing.(2017).Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation..Journal of Materials Chemistry B. |
| MLA | Sun Zhihong,et al."Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation.".Journal of Materials Chemistry B (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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