JSI-124 inhibits IgE production in an IgE B cell line.
文献类型：期刊论文
| 作者 | Wan, Xiaochun; Bi, Jiacheng; Cui, Lulu; Yan, Dehong; Ye, Xiufeng; Zheng, Mingxing; Yu, Guang |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | IgE is a key effector molecule in atopic diseases; however, the regulation mechanisms of IgE production in IgE B cells remain poorly understood. In the present study, we demonstrate that JSI-124 (cucurbitacin I), a selective STAT3 inhibitor, selectively inhibits production of IgE by a human IgE B cell line, CRL-8033 cells, while does not affect the IgG production by IgG B cell lines. In the aspect of molecular mechanism, we found that Igl, but not Ighe, gene expressionwas suppressed by JSI-124. The above effects of JSI-124 were not mediated by affecting cellular proliferation or apoptosis. Furthermore, multiple B cell differentiation-related genes expression was not significantly affected by JSI-124. Taken together, we demonstrate a potential strategy of therapeutically suppressing IgE production without affecting IgG production in atopic patients. (C) 2016 Elsevier Inc. All rights reserved. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12275]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| 推荐引用方式 GB/T 7714 | Wan, Xiaochun,Bi, Jiacheng,Cui, Lulu,et al. JSI-124 inhibits IgE production in an IgE B cell line.[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017. |
| APA | Wan, Xiaochun.,Bi, Jiacheng.,Cui, Lulu.,Yan, Dehong.,Ye, Xiufeng.,...&Yu, Guang.(2017).JSI-124 inhibits IgE production in an IgE B cell line..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. |
| MLA | Wan, Xiaochun,et al."JSI-124 inhibits IgE production in an IgE B cell line.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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