Regulation of NF-kappa B by PML and PML-RAR alpha.
文献类型：期刊论文
| 作者 | Lindsay AJ; Ahmed A; Wan X; Mitxitorena I; Paolo Pandolfi P; McCaffrey MW; Keeshan K; Chen YH; Carmody RJ |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting NF-κB activity. TNFα-treated PML−/− cells show normal IκBα degradation and NF-κB nuclear translocation but significantly reduced NF-κB DNA binding and phosphorylation of NF-κB p65. We also demonstrate that the PML retinoic acid receptor-α (PML-RARα) oncofusion protein, which causes acute promyelocytic leukemia, inhibits TNFα induced gene expression and phosphorylation of NF-κB. This study establishes PML as an important regulator of NF-κB and demonstrates that PML-RARα dysregulates NF-κB. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12278]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Scientific Reports |
| 推荐引用方式 GB/T 7714 | Lindsay AJ,Ahmed A,Wan X,et al. Regulation of NF-kappa B by PML and PML-RAR alpha.[J]. Scientific Reports,2017. |
| APA | Lindsay AJ.,Ahmed A.,Wan X.,Mitxitorena I.,Paolo Pandolfi P.,...&Carmody RJ.(2017).Regulation of NF-kappa B by PML and PML-RAR alpha..Scientific Reports. |
| MLA | Lindsay AJ,et al."Regulation of NF-kappa B by PML and PML-RAR alpha.".Scientific Reports (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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