DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression
文献类型：期刊论文
| 作者 | Dongming Li; Hongling Zhang; Xuhong Chen; Lulu Cui; Xin Li; Xiufeng Ye; Xiaochun Wan |
| 刊名 | Oncology Reports
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Decoy receptor 3 (DcR3), a decoy molecule belonging to the tumor necrosis factor receptor superfamily (TNFRSF), is a soluble receptor that can neutralize the biological effects of three other TNFSF members, namely, Fas ligand (FasL/TNFSF6/CD95L), LIGHT (TNFSF14) and TNF-like molecule 1A (TL1A/TNFSF15). DcR3 expression is increased in tumor cells. As such, DcR3 has been considered a potential biomarker to predict cancer invasion and progression of inflammation. However, the molecular mechanisms of DcR3 in tumor progression and metastasis remain poorly described. In the present study, DcR3 induced cytoskeleton remodeling, inhibited E-cadherin expression, and promoted cancer cell migration. Immunofluorescence and flow cytometry demonstrated that DcR3 expression was increased in hepatoma cells, whereas E-cadherin expression was significantly downregulated. Immunohistochemistry revealed that DcR3 and E-cadherin exhibited an opposite expression pattern between normal and cancerous liver tissues. Moreover, DcR3 treatment promoted IκBα degradation and p65 nuclear translocation. Therefore, the present study uncovered the mechanism underlying the function of DcR3 in cancer cell migration and provides evidence that DcR3 may be a potential target for cancer therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12279]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Oncology Reports |
| 推荐引用方式 GB/T 7714 | Dongming Li,Hongling Zhang,Xuhong Chen,et al. DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression[J]. Oncology Reports,2017. |
| APA | Dongming Li.,Hongling Zhang.,Xuhong Chen.,Lulu Cui.,Xin Li.,...&Xiaochun Wan.(2017).DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression.Oncology Reports. |
| MLA | Dongming Li,et al."DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression".Oncology Reports (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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