Generation of Bispecific Antibodies by Fc Heterodimerization and their Application
文献类型：期刊论文
| 作者 | Lishan Kang; Qi Zhao; Qifei Wang; Zhizhen Chen; Liping Wang; Tianshu Xu |
| 刊名 | CURRENT PHARMACEUTICAL BIOTECHNOLOGY
 |
| 出版日期 | 2016 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Bispecific antibodies with binding specificities for two different antigens have prompted a lot of interest into their development and application. Currently, more than ten bispecific antibodies have been clinically validated for the treatment of various diseases, including cancers and inflammatory diseases. Intensive studies in antibody engineering drive the generation of different bispecific antibody formats that differ in size and shape. However, the most prominent formats, such as IgG-single-chain (sc) Fv or dual-variable domain (DVD) IgG, deviating from the natural IgG structure, may lead to manufacturing difficulties or increase the potential risk of immunogenicity. Thus, the recent efforts focus on the development of bispecific antibodies by Fc heterodimerization that maintain the native structure of the antibody IgG molecule. This review summarizes the various techniques and methods to generate bispecific antibody molecules with Fc heterodimerization, and discusses perspectives of their application. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12281]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | CURRENT PHARMACEUTICAL BIOTECHNOLOGY |
| 推荐引用方式 GB/T 7714 | Lishan Kang,Qi Zhao,Qifei Wang,et al. Generation of Bispecific Antibodies by Fc Heterodimerization and their Application[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2016. |
| APA | Lishan Kang,Qi Zhao,Qifei Wang,Zhizhen Chen,Liping Wang,&Tianshu Xu.(2016).Generation of Bispecific Antibodies by Fc Heterodimerization and their Application.CURRENT PHARMACEUTICAL BIOTECHNOLOGY. |
| MLA | Lishan Kang,et al."Generation of Bispecific Antibodies by Fc Heterodimerization and their Application".CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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