NK Cell exhaustion.
文献类型：期刊论文
| 作者 | Tian, Zhigang; Bi, Jiacheng |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12283]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | FRONTIERS IN IMMUNOLOGY |
| 推荐引用方式 GB/T 7714 | Tian, Zhigang,Bi, Jiacheng. NK Cell exhaustion.[J]. FRONTIERS IN IMMUNOLOGY,2017. |
| APA | Tian, Zhigang,&Bi, Jiacheng.(2017).NK Cell exhaustion..FRONTIERS IN IMMUNOLOGY. |
| MLA | Tian, Zhigang,et al."NK Cell exhaustion.".FRONTIERS IN IMMUNOLOGY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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