Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy
文献类型：期刊论文
| 作者 | Paul K. Chu; Zhibin Li; Jundong Shao; Qian Luo; Xue-Feng Yu; Hanhan Xie; Haidi Fu; Siying Tang; Huaiyu Wang; Guangli Han |
| 刊名 | Biomaterials
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Two of the challenges for clinical implementation of nano-therapeutic strategies are optimization of tumor targeting and clearance of the nanoagents in vivo. Herein, a cell-mediated therapy by transporting 2D Bi2Se3 nanosheets within macrophage vehicles is described. The Bi2Se3 nanosheets with excellent near-infrared photothermal performance exhibit high macrophage uptake and negligible cytotoxicity thus facilitating the fabrication of Bi2Se3-laden-macrophages. Compared with bare Bi2Se3, the Bi2Se3-laden-macrophages after intravenous injection show prolonged blood circulation and can overcome the hypoxia-associated drug delivery barrier to target the tumor efficiently and dramatically enhance the efficiency of photothermal cancer therapy. The Bi2Se3-laden-macrophages possess good biocompatibility as demonstrated by the biochemical and histological analyses and furthermore, most of the materials are excreted from the body within 25 days. Our findings reveal a desirable system for highly efficient nearinfrared photothermal cancer therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12297]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Biomaterials |
| 推荐引用方式 GB/T 7714 | Paul K. Chu,Zhibin Li,Jundong Shao,et al. Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy[J]. Biomaterials,2017. |
| APA | Paul K. Chu.,Zhibin Li.,Jundong Shao.,Qian Luo.,Xue-Feng Yu.,...&Guangli Han.(2017).Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy.Biomaterials. |
| MLA | Paul K. Chu,et al."Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy".Biomaterials (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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