Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics
文献类型：期刊论文
| 作者 | Hamad-Schifferli Kimberly; Gao Jie; Sanchez-Purra Maria; Huang Hao; Wang Shunhao; Chen Yunan; Yu Xuefeng; Luo Qian; Liu Sijin |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Gold nanoparticles (AuNPs) have been attractive for nanomedicine because of their pronounced optical properties. Here, we customerized the methods to synthesize two types of gold nanostars, Au nanostars-1 and Au nanostars-2, which have different spire lengths and optical properties, and also spherical AuNPs. Compared to nanospheres, gold nanostars were less toxic to a variety of cells, including macrophages. Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres, and but reveled less liver retention than nanospheres. Due to their strong absorption in the near-infrared (NIR), Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm, and elicited a robust photothermal therapy (PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells. Meanwhile, Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy (SERS) in 4T1 cells. Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12305]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | SCIENCE CHINA-CHEMISTRY |
| 推荐引用方式 GB/T 7714 | Hamad-Schifferli Kimberly,Gao Jie,Sanchez-Purra Maria,et al. Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics[J]. SCIENCE CHINA-CHEMISTRY,2017. |
| APA | Hamad-Schifferli Kimberly.,Gao Jie.,Sanchez-Purra Maria.,Huang Hao.,Wang Shunhao.,...&Liu Sijin.(2017).Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics.SCIENCE CHINA-CHEMISTRY. |
| MLA | Hamad-Schifferli Kimberly,et al."Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics".SCIENCE CHINA-CHEMISTRY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。