Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics
文献类型：期刊论文
| 作者 | Jia Liu; Xinyi Leng; Haiqiang Qin; Xin Liu; Baixue Jia; Ligang Song; Yilong Wang; Zhongrong Miao; Yongjun Wang; Liping Liu |
| 刊名 | Journal of Cerebral Blood Flow & Metabolism
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The fractional pressure ratio is introduced to quantitatively assess the hemodynamic significance of severe intracranial stenosis. A computational fluid dynamics-based method is proposed to non-invasively compute the FPRCFD and compared against fractional pressure ratio measured by an invasive technique. Eleven patients with severe intracranial stenosis considered for endovascular intervention were recruited and an invasive procedure was performed to measure the distal and the aortic pressure ( Pd and Pa). The fractional pressure ratio was calculated as [Formula: see text]. The computed tomography angiography was used to reconstruct three-dimensional (3D) arteries for each patient. Cerebral hemodynamics was then computed for the arteries using a mathematical model governed by Navier-Stokes equations and with the outflow conditions imposed by a model of distal resistance and compliance. The non-invasive [Formula: see text], [Formula: see text], and FPRCFD were then obtained from the computational fluid dynamics calculation using a 16-core parallel computer. The invasive and non-invasive parameters were tested by statistical analysis. For this group of patients, the computational fluid dynamics method achieved comparable results with the invasive measurements. The fractional pressure ratio and FPRCFD are very close and highly correlated, but not linearly proportional, with the percentage of stenosis. The proposed computational fluid dynamics method can potentially be useful in assessing the functional alteration of cerebral stenosis. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12574]  |
| 专题 | 深圳先进技术研究院_数字所 |
| 作者单位 | Journal of Cerebral Blood Flow & Metabolism |
| 推荐引用方式 GB/T 7714 | Jia Liu,Xinyi Leng,Haiqiang Qin,et al. Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics[J]. Journal of Cerebral Blood Flow & Metabolism,2017. |
| APA | Jia Liu.,Xinyi Leng.,Haiqiang Qin.,Xin Liu.,Baixue Jia.,...&Rongliang Chen.(2017).Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics.Journal of Cerebral Blood Flow & Metabolism. |
| MLA | Jia Liu,et al."Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics".Journal of Cerebral Blood Flow & Metabolism (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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