中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.

文献类型:期刊论文

作者Li, Xia; Huang, Hailiang; Guan, Yanfang; Gong, Yuhua; He, Cheng-Yi; Yi, Xin; Qi, Ming; Chen, Zhi-Ying
刊名CANCER MEDICINE
出版日期2017
文献子类期刊论文
英文摘要Emerging evidence suggest that the heterogeneity of cancer limits the efficacy of immunotherapy. To search for optimal therapeutic targets for enhancing the efficacy, we used whole-exome sequencing data of 23 early cervical tumors from Chinese women to investigate the hierarchical structure of the somatic mutations and the neo-epitopes. The putative neo-epitopes were predicted based on the mutant peptides' strong binding with major histocompatibility complex class I molecules. We found that each tumor carried an average of 117 mutations and 61 putative neo-epitopes. Each patient displayed a unique phylogenetic tree in which almost all subclones harbored neo-epitopes, highlighting the importance of individual neo-epitope tree in determination of immunotherapeutic targets. The alterations in FBXW7 and PIK3CA, or other members of the significantly altered ubiquitin-mediated proteolysis and extracellular matrix receptor interaction related pathways, were proposed as the earliest changes triggering the malignant progression. The neo-epitopes involved in these pathways, and located at the top of the hierarchy tree, might become the optimal candidates for therapeutic targets, possessing the potential to mediate T-cell killing of the descendant cells. These findings expanded our understanding in early stage of cervical carcinogenesis and offered an important approach to assist optimizing the immunotherapeutic target selection.
URL标识查看原文
语种英语
源URL[http://ir.siat.ac.cn:8080/handle/172644/12597]  
专题深圳先进技术研究院_数字所
作者单位CANCER MEDICINE
推荐引用方式
GB/T 7714
Li, Xia,Huang, Hailiang,Guan, Yanfang,et al. Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.[J]. CANCER MEDICINE,2017.
APA Li, Xia.,Huang, Hailiang.,Guan, Yanfang.,Gong, Yuhua.,He, Cheng-Yi.,...&Chen, Zhi-Ying.(2017).Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women..CANCER MEDICINE.
MLA Li, Xia,et al."Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.".CANCER MEDICINE (2017).

入库方式: OAI收割

来源:深圳先进技术研究院

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