Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.
文献类型:期刊论文
作者 | Li, Xia; Huang, Hailiang; Guan, Yanfang; Gong, Yuhua; He, Cheng-Yi; Yi, Xin; Qi, Ming; Chen, Zhi-Ying |
刊名 | CANCER MEDICINE |
出版日期 | 2017 |
文献子类 | 期刊论文 |
英文摘要 | Emerging evidence suggest that the heterogeneity of cancer limits the efficacy of immunotherapy. To search for optimal therapeutic targets for enhancing the efficacy, we used whole-exome sequencing data of 23 early cervical tumors from Chinese women to investigate the hierarchical structure of the somatic mutations and the neo-epitopes. The putative neo-epitopes were predicted based on the mutant peptides' strong binding with major histocompatibility complex class I molecules. We found that each tumor carried an average of 117 mutations and 61 putative neo-epitopes. Each patient displayed a unique phylogenetic tree in which almost all subclones harbored neo-epitopes, highlighting the importance of individual neo-epitope tree in determination of immunotherapeutic targets. The alterations in FBXW7 and PIK3CA, or other members of the significantly altered ubiquitin-mediated proteolysis and extracellular matrix receptor interaction related pathways, were proposed as the earliest changes triggering the malignant progression. The neo-epitopes involved in these pathways, and located at the top of the hierarchy tree, might become the optimal candidates for therapeutic targets, possessing the potential to mediate T-cell killing of the descendant cells. These findings expanded our understanding in early stage of cervical carcinogenesis and offered an important approach to assist optimizing the immunotherapeutic target selection. |
URL标识 | 查看原文 |
语种 | 英语 |
源URL | [http://ir.siat.ac.cn:8080/handle/172644/12597] |
专题 | 深圳先进技术研究院_数字所 |
作者单位 | CANCER MEDICINE |
推荐引用方式 GB/T 7714 | Li, Xia,Huang, Hailiang,Guan, Yanfang,et al. Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.[J]. CANCER MEDICINE,2017. |
APA | Li, Xia.,Huang, Hailiang.,Guan, Yanfang.,Gong, Yuhua.,He, Cheng-Yi.,...&Chen, Zhi-Ying.(2017).Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women..CANCER MEDICINE. |
MLA | Li, Xia,et al."Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.".CANCER MEDICINE (2017). |
入库方式: OAI收割
来源:深圳先进技术研究院
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