Analyses of the Dual Immune Roles Cytokines Play in Ischemic Stroke
文献类型：会议论文
| 作者 | Haibo Yu; Yingying Wang; Jianfeng Liu; Yunpeng Cai |
| 出版日期 | 2017 |
| 会议日期 | 2017 |
| 会议地点 | Pushchino, Moscow Region, Russia |
| 英文摘要 | Stroke is one of the leading causes of morbidity and permanent disability worldwide. There is a need for an efficacious alternative therapy administered beyond the limitation of time window based on the biological characteristics of stroke, currently. The immunomodulatory therapy could extend the time window while not increase the risk of hemorrhage which made it become candidate treatments. In this paper, we integrated several gene expression profiles generated from the peripheral blood of ischemic stroke patients and health people. Differential expressed cytokines were first selected as candidate cytokines. Enrichment analyses were then performed to filter the candidate cytokines as biomarkers (E-CKs) by checking the relationships between them and the stroke related functional terms. More cytokines were found as biomarkers in the subacute stage of ischemic stroke compared with acute and chronic stages which could be explained by the great changes in microenvironment in this necrosis stage. Analyses based on microRNomics level showed that more E-CKs one miRNA regulated, the more important role it played in stroke related processes. Similarly, analyses on proteomics level showed that E-CKs with top degrees in the protein-protein interaction network were proved to be closely related to stroke. Most E-CKs participate in both the stroke processing and rehabilitation, thus, the dual immune characters made them become valuable potential targets of immunomodulatory therapies. |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12705]  |
| 专题 | 深圳先进技术研究院_数字所 |
| 作者单位 | 2017 |
| 推荐引用方式 GB/T 7714 | Haibo Yu,Yingying Wang,Jianfeng Liu,et al. Analyses of the Dual Immune Roles Cytokines Play in Ischemic Stroke[C]. 见:. Pushchino, Moscow Region, Russia. 2017. |
入库方式： OAI收割
来源：深圳先进技术研究院
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