2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.
文献类型：期刊论文
| 作者 | Qian Luo; Paul K. Chu; Xue-Feng Yu; Wenhua Zhou; Huaiyu Wang; Hanhan Xie; Jundong Shao |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (Bi2Se3) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability. Cell experiments and hematological analyses demonstrate that the Bi2Se3/PLLA membranes have excellent biocompatibility and low toxicity. PTT experiments performed in vivo with the Bi2Se3/PLLA membrane covering the tumor and NIR irradiation produce local hyperthermia to ablate the tumor with high efficiency. Different from the traditional systematical and local injection techniques, this membrane-based PTT platform is promising in photothermal cancer therapy, especially suitable for the treatment of multiple solid tumors or skin cancers, and long-term prevention of cancer recurrence after surgery or PTT, while eliminating the health hazards of nanoagents. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12318]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS APPLIED MATERIALS & INTERFACES |
| 推荐引用方式 GB/T 7714 | Qian Luo,Paul K. Chu,Xue-Feng Yu,et al. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.[J]. ACS APPLIED MATERIALS & INTERFACES,2017. |
| APA | Qian Luo.,Paul K. Chu.,Xue-Feng Yu.,Wenhua Zhou.,Huaiyu Wang.,...&Jundong Shao.(2017).2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy..ACS APPLIED MATERIALS & INTERFACES. |
| MLA | Qian Luo,et al."2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.".ACS APPLIED MATERIALS & INTERFACES (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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