Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.
文献类型：期刊论文
| 作者 | Cui, Wenguo; Zhao, Xin; Pan, Guoqing; Zhang, Ying; Cheng, Liying; Zhang, Hongbo; Lang, Qi; Sun, Xiaoming; Zhang, Yuguang; Santos, Helder A. |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Distal necrosis of random skin flap is always clinical problematic in plastic surgery. The development of 3D functional vascular networks is fundamental for the survival of a local random skin flap. Herein, an effective technique on constructing 3D fibrous scaffolds for accelerated vascularization is demonstrated using a photocrosslinkable natural hydrogel based on gelatin methacryloyl (GelMA) by electrospinning. It is found that the ultraviolet (UV) photocrosslinkable gelatin electrospun hydrogel fibrous membranes exhibit soft adjustable mechanical properties and controllable degradation properties. Furthermore, it is observed that the optimized hydrogel scaffolds can support endothelial cells and dermal fibroblasts adhesion, proliferation, and migration into the scaffolds, which facilitates vascularization. Importantly, a rapid formation of tubes is observed after 3 d seeding of endothelial cells. After GelMA fibrous scaffold implantation below the skin flap in a rat model, it is found that the flap survival rate is higher than the control group, and there is more microvascular formation, which is potentially beneficial for the flap tissue vascularization. These data suggest that GelMA hydrogels can be used for biomedical applications that require the formation of microvascular networks, including the development of complex engineered tissues. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12321]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ADVANCED FUNCTIONAL MATERIALS |
| 推荐引用方式 GB/T 7714 | Cui, Wenguo,Zhao, Xin,Pan, Guoqing,et al. Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.[J]. ADVANCED FUNCTIONAL MATERIALS,2017. |
| APA | Cui, Wenguo.,Zhao, Xin.,Pan, Guoqing.,Zhang, Ying.,Cheng, Liying.,...&Yang, Huilin.(2017).Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration..ADVANCED FUNCTIONAL MATERIALS. |
| MLA | Cui, Wenguo,et al."Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.".ADVANCED FUNCTIONAL MATERIALS (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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