Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.
文献类型：期刊论文
| 作者 | Elieh-Ali-Komi, Daniel; Cao, Yonghao |
| 刊名 | CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Multiple sclerosis (MS) is a neurological autoimmune disorder of the central nervous system (CNS), characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. The hallmark of the disease is the demyelinated plaque, a hypocellular area characterized by formation ofastrocytic scars and infiltration of mononuclear cells. Recent studies have revealed that both innate and adaptive immune cells contribute to the pathogenesisof MS and its experimental autoimmune encephalomyelitis (EAE) model. Here, we review the current understanding of the role of mast cells in thepathogenesis of MS and EAE. Mast cells may act at the early stage that promote demyelination through interactions among mast cells, neurons, and other immune cells to mediate neuroinflammation. Studies from EAE model suggest that mast cells regulate adaptive autoimmune responses, present myelin antigens to T cells, disrupt the blood-brain barrier, and permit the entry of inflammatory cells and mediators into the CNS. Depletion or limiting mast cells could be a new promising therapeutic target for MS and EAE. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12328]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY |
| 推荐引用方式 GB/T 7714 | Elieh-Ali-Komi, Daniel,Cao, Yonghao. Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.[J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY,2017. |
| APA | Elieh-Ali-Komi, Daniel,&Cao, Yonghao.(2017).Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis..CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY. |
| MLA | Elieh-Ali-Komi, Daniel,et al."Role of Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.".CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。