Drug detoxification dynamics explain the postantibiotic effect.
文献类型：期刊论文
| 作者 | Lopatkin, Allison J.; Srimani, Jaydeep K.; Huang, Shuqiang; You, Lingchong |
| 刊名 | MOLECULAR SYSTEMS BIOLOGY
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The postantibiotic effect (PAE) refers to the temporary suppression of bacterial growth following transient antibiotic treatment. This effect has been observed for decades for a wide variety of antibiotics and microbial species. However, despite empirical observations, a mechanistic understanding of this phenomenon is lacking. Using a combination of modeling and quantitative experiments, we show that the PAE can be explained by the temporal dynamics of drugdetoxification in individual cells after an antibiotic is removed from the extracellular environment. These dynamics are dictated by both the export of theantibiotic and the intracellular titration of the antibiotic by its target. This mechanism is generally applicable for antibiotics with different modes of action. We further show that efflux inhibition is effective against certain antibiotic motifs, which may help explain mixed cotreatment success. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12337]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | MOLECULAR SYSTEMS BIOLOGY |
| 推荐引用方式 GB/T 7714 | Lopatkin, Allison J.,Srimani, Jaydeep K.,Huang, Shuqiang,et al. Drug detoxification dynamics explain the postantibiotic effect.[J]. MOLECULAR SYSTEMS BIOLOGY,2017. |
| APA | Lopatkin, Allison J.,Srimani, Jaydeep K.,Huang, Shuqiang,&You, Lingchong.(2017).Drug detoxification dynamics explain the postantibiotic effect..MOLECULAR SYSTEMS BIOLOGY. |
| MLA | Lopatkin, Allison J.,et al."Drug detoxification dynamics explain the postantibiotic effect.".MOLECULAR SYSTEMS BIOLOGY (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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