Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials.
文献类型：期刊论文
| 作者 | Pan, Haobo; Ma, Yufei; Liu, Juan; Luo, Min; Xing, Juan; Ruan, Changshun; Luo, Yanfeng |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | One key limitation to the application of linear biodegradable polyurethanes (LBPUs) in scaffoldmaterials for bone regeneration is their insufficientmechanical properties. In this study, isosorbide (ISO), a rigid two-ring small diol is selected as a chain extender to produce a series of new poly (D, L-lactide)-based polyurethanes (ISO-PUs). It is confirmed that incorporating ISO as the chain extender can significantly reduce the crosslinking degree of ISO-PUs and thus increase their molecular weight and mechanical properties. ISO-PUs with Mn values of 72.09 kDa and 84.79 kDa demonstrate higher tensile strength & modulus (39.87 MPa & 2.19 GPa and 42.68 MPa & 2.57 GPa) than PDLLA with a M-n of 100 kDa (36.15 MPa & 2.07 GPa). All these results, together with the sound cytocompatibility of ISO-PUs with MC3T3-E1 cells based on the morphology observation and cell proliferation, suggest that ISO-PU should be a promising scaffold material for bone regeneration. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12353]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | RSC ADVANCES |
| 推荐引用方式 GB/T 7714 | Pan, Haobo,Ma, Yufei,Liu, Juan,et al. Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials.[J]. RSC ADVANCES,2017. |
| APA | Pan, Haobo.,Ma, Yufei.,Liu, Juan.,Luo, Min.,Xing, Juan.,...&Luo, Yanfeng.(2017).Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials..RSC ADVANCES. |
| MLA | Pan, Haobo,et al."Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials.".RSC ADVANCES (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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