Small leucine-rich proteoglycans (SLRPs): characteristics and function in the intervertebral disc.
文献类型：期刊论文
| 作者 | Leung, Victor Y. L; Huang, Shishu; Chen, Lili; Liao, Jingwen; Klineberg, Eric |
| 刊名 | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The intervertebral disc (IVD) is responsible for normal spinal motion and load distribution. However, degeneration may occur due to age-and non-age-related processes and is primarily characterized by a reduction in the number of chondrocyte-like cells and abnormal extracellular matrix (ECM) structure in the nucleus pulposus. Although IVD progenitor cells have been identified, the local microenvironment components regulating the behaviour of these progenitor cell populations remain unknown. Small leucine-rich proteoglycans (SLRPs) are bioactive components of the ECM associated with fibrillogenesis, cellular growth and apoptosis and tissue remodelling. SLRPs support the survival of IVD progenitor cells under hypoxic conditions via the activation of specific hypoxia-inducible factors. Additionally, SLRPs deficiency (biglycan) in knockout mice is sufficient to accelerate the IVD degenerative process. These data suggest that SLRPs play an important role in the homeostasis of IVD. Given their specific properties and physiological functions, we propose a role of SLRPs in IVD degeneration and potential application in its regeneration. Copyright (C) 2015 John Wiley & Sons, Ltd. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12354]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE |
| 推荐引用方式 GB/T 7714 | Leung, Victor Y. L,Huang, Shishu,Chen, Lili,et al. Small leucine-rich proteoglycans (SLRPs): characteristics and function in the intervertebral disc.[J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2017. |
| APA | Leung, Victor Y. L,Huang, Shishu,Chen, Lili,Liao, Jingwen,&Klineberg, Eric.(2017).Small leucine-rich proteoglycans (SLRPs): characteristics and function in the intervertebral disc..JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. |
| MLA | Leung, Victor Y. L,et al."Small leucine-rich proteoglycans (SLRPs): characteristics and function in the intervertebral disc.".JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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