3D-printed high strength bioactive supramolecular polymer/clay nanocomposite hydrogel scaffold for bone regeneration
文献类型：期刊论文
| 作者 | Yinyu Zhang; Changshun Ruan; Haobo Pan; Wenguang Liu; W. Lu; Xinyun Zhai; Yufei Ma; Chunyong Hou; Fei Gao |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The emerging 3D bioprinting technique that is strongly dependent on the development of bioinks offers a promising opportunity to customize personalized bioscaffolds for precision and individualized therapy of bone defects. Hydrogels are one sort of attractive scaffolding materials due to their resemblance to extracellular matrices. Although much progress has been made in designing and fabricating high strength hydrogels, very few of them have been extended to the treatment of bone defects. In this work, we developed a hybrid bioink composed of a hydrogen bonding monomer (N-acryloyl glycinamide) (NAGA) and nanoclay. The hybrid ink could be conveniently tailored as a high strength PNAGA-Clay composite scaffold under UV light illumination of printed prehydrogel. The hydrogen bonding combined with physical cross-linking of nanoclay contributed to the superior mechanical performances as well as swelling stability of the hydrogels and bioscaffols. The sustainable release of intrinsic Mg2+ and Si4+ from the PNAGA-Clay scaffold was shown to promote the osteogenic differentiation of primary rat osteoblast (ROB) cells. Importantly, this implantable PNAGA-Clay scaffold highly efficiently facilitated the regeneration of new bone in tibia defects of rats. We anticipate that hybridization of the hydrogen bonding monomer with a variety of bioactive inorganic nanoparticles will offer new possibilities to develop numerous bioinks for 3D-printing of desired bioscaffolds to realize individualized repair of degenerated load-bearing tissues. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12355]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS BIOMATERIALS SCIENCE & ENGINEERING |
| 推荐引用方式 GB/T 7714 | Yinyu Zhang,Changshun Ruan,Haobo Pan,et al. 3D-printed high strength bioactive supramolecular polymer/clay nanocomposite hydrogel scaffold for bone regeneration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING ,2017. |
| APA | Yinyu Zhang.,Changshun Ruan.,Haobo Pan.,Wenguang Liu.,W. Lu.,...&Fei Gao.(2017).3D-printed high strength bioactive supramolecular polymer/clay nanocomposite hydrogel scaffold for bone regeneration.ACS BIOMATERIALS SCIENCE & ENGINEERING . |
| MLA | Yinyu Zhang,et al."3D-printed high strength bioactive supramolecular polymer/clay nanocomposite hydrogel scaffold for bone regeneration".ACS BIOMATERIALS SCIENCE & ENGINEERING (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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