The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.
文献类型：期刊论文
| 作者 | Mao, Congyang; Xie, Xianzhou; Liu, Xiangmei; Cui, Zhenduo; Yang, Xianjin; Yeung, K. W. K.; Pan, Haobo; Chu, Paul K.; Wu, Shuilin |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In this study, we prepared pH-sensitive hybrid nanospheres through the implementation of a facile molecularly imprinted polymer (MIP) technique combined with a UV-initiated precipitation polymerization method using vancomycin (VA) for the templates. During the course of this investigation, both 2-hydroxyethyl methacrylate (HEMA) and 2-(diethylamino) ethyl methacrylate (DEAEMA) were utilized as the functional monomers, while ethylene glycol dimethacrylate (EGDMA) was used as a cross-linker. The obtained MIP nanospheres exhibited well-controlled particle size, with a drug loading capacity of about 17%, much higher than that of the non imprinted polymer (NIP) nanospheres (5%). In addition, the VA loading quantity was closely correlated with the dosage of the cross-linking agent, and the MIP nanospheres exhibited a slower and more controlled VA release rate than the NIP nanospheres. Moreover, these MIP nanosphereswere sensitive to pH values, and consequently showed an increasing release rate of VA as the pH level was decreased. The VA-loaded MIP nanospheresshowed the higher antibacterial ratio of over 92% against Staphylococcus aureus (S. aureus) while the NIP nano spheres were friendly to S. aureus. These MIPnanospheres can be promising for targeting drug delivery system to achieve specific therapies such as preventing bacterial infections and killing cancer cells without damaging health cells and tissues. (C) 2017 Elsevier B.V. All rights reserved. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12363]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS |
| 推荐引用方式 GB/T 7714 | Mao, Congyang,Xie, Xianzhou,Liu, Xiangmei,et al. The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017. |
| APA | Mao, Congyang.,Xie, Xianzhou.,Liu, Xiangmei.,Cui, Zhenduo.,Yang, Xianjin.,...&Wu, Shuilin.(2017).The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity..MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. |
| MLA | Mao, Congyang,et al."The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity.".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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