Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass.
文献类型：期刊论文
| 作者 | Cui, Xu; Huang, Chengcheng; Zhang, Meng; Ruan, Changshun; Peng, Songlin; Li, Li; Liu, Wenlong; Wang, Ting; Li, Bing; Huang, Wenhai |
| 刊名 | JOURNAL OF THE ROYAL SOCIETY INTERFACE
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength. The bioactivity of SrBG/PMMA composite cements was confirmed in vitro, evidenced byion release (Ca, P, B and Sr) from SrBG particles. The cellular responses of MC3T3-E1 cells in vitro demonstrated that SrBG incorporation could promote adhesion, migration, proliferation and collagen secretion of cells. Furthermore, our in vivo investigation revealed that SrBG/PMMA composite cementspresented better osseointegration than PMMA bone cement. SrBG in the composite cement could stimulate new-bone formation around the interface between the composite cement and host bone at eight and 12 weeks post-implantation, whereas PMMA bone cement only stimulated development of an intervening connective tissue layer. Consequently, the SrBG/PMMA composite cement may be a better alternative to PMMA cement in clinical applications and has promising orthopaedic applications by minimal invasive surgery. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12366]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF THE ROYAL SOCIETY INTERFACE |
| 推荐引用方式 GB/T 7714 | Cui, Xu,Huang, Chengcheng,Zhang, Meng,et al. Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass.[J]. JOURNAL OF THE ROYAL SOCIETY INTERFACE,2017. |
| APA | Cui, Xu.,Huang, Chengcheng.,Zhang, Meng.,Ruan, Changshun.,Peng, Songlin.,...&Pan, Haobo.(2017).Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass..JOURNAL OF THE ROYAL SOCIETY INTERFACE. |
| MLA | Cui, Xu,et al."Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass.".JOURNAL OF THE ROYAL SOCIETY INTERFACE (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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